The Swede is struggling with an Achilles injury, according to Sky Sport Italia.
The 39-year-old scored 48 times in 120 appearances in the competition during his time at Inter and PSG.
The soon-to-be 40-year-old was expected to play against the Premier League side, but coach Stefano Pioli will be without Ibrahimovic.
Meanwhile, Olivier Giroud has returned to Milan after spending the international break in fiduciary isolation following a positive coronavirus test.
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