Defending champions Real Madrid crashed out of the Champions League as Ajax produced a stunning 4-1 victory in the Santiago Bernabeu to reach the quarter-finals.
Captain Sergio Ramos was suspended after deliberately collecting a yellow card in the first leg, Real Madrid were forced into two changes when Lucas Vazquez and Vinicius
Junior went off injured, with substitute Gareth Bale hitting the post
just before half-time.
However, after Raphael Varane's header rattled the crossbar, Ajax raced into an early lead through Hakim Ziyech before Dusan Tadic set up David Neres for a second in the 18th minute.
Ajax's Tadic swept in a brilliant third goal just after the hour which was given following an extensive Video Assistant Referee review to check if the ball had gone out of play in the build-up.
Meanwhile, Substitute Marco Asensio briefly gave Real hope when he put the ball in off the post with 20 minutes left.
Real finished with 10 men after Nacho picked up two needless late cautions.
The defeat was a fourth successive home loss for Real following after losing to arch-rivals Barcelona in La Liga on Saturday and will see pressure mount on manager Santiago Solari.
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